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生きてる酵素 りたん遺伝子解析 d_スタジオ

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2017/02/10 09:05 葉酸 peg - Google News

12/01 18:02 次世代放射光施設検討ワーキンググループ(第4回) 議事録 - 文部科学省
12/01 18:02 次世代放射光施設検討ワーキンググループ(第4回) 議事録 - 文部科学省

次世代放射光施設検討ワーキンググループ(第4回) 議事録
文部科学省
これは近年、アメリカのAvidimer、こういうベンチャー会社が実はデンドリマーに葉酸と制がん剤をくっつけたこういうDDSですけれども、非常にこれ、制がん効果がありましたから、ものすごくお金を集めてベンチャーを作ったんです。FDAの審査まで行ったのですけれども、 .... 【櫻井委員】 今、FDAのCDERの態度は、昔は高 ...

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02/29 04:05 薬食審・第二部会 新薬など9製品を審議、承認了承 4製品は抗がん剤 - ミクスOnline
02/29 04:05 薬食審・第二部会 新薬など9製品を審議、承認了承 4製品は抗がん剤 - ミクスOnline

薬食審・第二部会 新薬など9製品を審議、承認了承 4製品は抗がん剤
ミクスOnline
既存のアドベイト静注用の有効成分であるルリオクトコグ アルファ(遺伝子組換え)に分子量約20kDaのポリエチレングリコールPEG)を結合させた遺伝子組換え血液凝固第8因子製剤。PEG化することでアドベイト静注用よりも血中半減期を延長させた。これにより投与頻度は ...

08/07 16:23 「レクチノーラル タブレット」「レクチノーラル デンタルジェル」8月10日(月)からウェブサイトで新発売 - 共同通信PRワイヤー (プレスリリース)
08/07 16:23 「レクチノーラル タブレット」「レクチノーラル デンタルジェル」8月10日(月)からウェブサイトで新発売 - 共同通信PRワイヤー (プレスリリース)

共同通信PRワイヤー (プレスリリース)

「レクチノーラル タブレット」「レクチノーラル デンタルジェル」8月10日(月)からウェブサイトで新発売
共同通信PRワイヤー (プレスリリース)
... セルロース、ラクトフェリン(乳由来)、微粒酸化ケイ素、香料、HPC、ステアリン酸カルシウム、シェラック、グルコースオキシターゼ、ラクトパーオキシターゼ(乳由来)、グァーガム、葉酸、カルナウバロウアレルギー物質(27品目中): 乳包装・価格: 希望小売価格4,860円(税込) ... 剤/キシリトール、湿潤剤/ミルエキ ...

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01/25 11:22 アレルギーの季節到来!乳幼児期から予防対策を アレルギーを感じる人は3・4月にかけてピークに! - PR TIMES (プレスリリース)
01/25 11:22 アレルギーの季節到来!乳幼児期から予防対策を アレルギーを感じる人は3・4月にかけてピークに! - PR TIMES (プレスリリース)

PR TIMES (プレスリリース)

アレルギーの季節到来!乳幼児期から予防対策を アレルギーを感じる人は3・4月にかけてピークに!
PR TIMES (プレスリリース)
雪印メグミルクグループのビーンスターク・スノー株式会社(本社:東京都新宿区 代表取締役社長:平田公孝)は、0~3歳の子どもを持つ25歳~45歳の親、男女400人(既婚者のパパ、ママ各200人)を対象に、アレルギーに関する意識を把握することを目的として、2016年1月9 ...

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11/25 11:26 リキッドのうるおいとパウダリーの手軽さ『リキッドヴェールファンデーション』を発売/ハーバー研究所 - 健康美容EXPO
11/25 11:26 リキッドのうるおいとパウダリーの手軽さ『リキッドヴェールファンデーション』を発売/ハーバー研究所 - 健康美容EXPO

健康美容EXPO

リキッドのうるおいとパウダリーの手軽さ『リキッドヴェールファンデーション』を発売/ハーバー研究所
健康美容EXPO
配合成分 水、シクロペンタシロキサン、BG、ジエチルへキサン酸ネオペンチルグリコール、グリセリン、PEG-10ジメチコン、ペンチレングリコール、スクワラン、トコフェロール、ヒアルロン酸Na、プルーン分解物、ソメイヨシノ葉エキス、ヒメフウロエキス、アーチチョーク葉エキス、加水分解水添デンプン、グリコシルトレハロース、(ビニルジメチコン ...

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09/08 04:04 薬食審・第ニ部会 新薬など6成分を審議 承認了承 ファイザーの新規CML治療薬も - ミクスOnline
09/08 04:04 薬食審・第ニ部会 新薬など6成分を審議 承認了承 ファイザーの新規CML治療薬も - ミクスOnline

薬食審・第ニ部会 新薬など6成分を審議 承認了承 ファイザーの新規CML治療薬も
ミクスOnline
ペグインターフェロンアルファ-2b(遺伝子組換え)、リバビリンと併用して用いる。類薬にはテラビック(テラプレビル、田辺三菱)やソブリアード(シメプレビル、ヤンセン)がある。C型肝炎の推定感染患者数は150~200万人。この7割程度が慢性肝炎に移行するとされる。

11/30 05:14 薬食審・第二部会 新薬など5成分を審議、承認了承 RAの生物製剤も - ミクスOnline
11/30 05:14 薬食審・第二部会 新薬など5成分を審議、承認了承 RAの生物製剤も - ミクスOnline

薬食審・第二部会 新薬など5成分を審議、承認了承 RAの生物製剤も
ミクスOnline
同剤はPEG化抗TNF-α抗体の生物学的製剤。順調にいけば春前の薬価収載になるとみられ、発売後は免疫・炎症領域に強いアステラス製薬とコ・プロモーションすることになっている。 RA治療薬としての生物学的製剤にはほかに、レミケード(田辺三菱)、エンブレル(ファイザー/ ...

09/08 04:04 中外 ALK陽性非小細胞肺がん治療薬アレセンサカプセルを新発売 - ミクスOnline
09/08 04:04 中外 ALK陽性非小細胞肺がん治療薬アレセンサカプセルを新発売 - ミクスOnline

中外 ALK陽性非小細胞肺がん治療薬アレセンサカプセルを新発売
ミクスOnline
中外製薬は9月5日、ALK陽性非小細胞肺がん治療薬アレセンサカプセル20mg、同40mg(一般名:アレクチニブ塩酸塩)を同日に新発売したと発表した。承認条件となっている全例調査では1000例の集積を目標とし、同じく承認条件の流通管理では施設要件や医師要件を ...

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12/26 05:08 新薬14成分が承認 RA治療の生物学的製剤や経口抗凝固薬など - ミクスOnline
12/26 05:08 新薬14成分が承認 RA治療の生物学的製剤や経口抗凝固薬など - ミクスOnline

新薬14成分が承認 RA治療の生物学的製剤や経口抗凝固薬など
ミクスOnline
厚労省は12月25日、新薬として14成分23品目を承認した。生物学的製剤で関節リウマチ(RA)治療薬シムジア皮下注(成分名:セルトリズマブ ペゴル、会社名:ユーシービージャパン)や経口抗凝固薬エリキュース錠(アピキサバン、ブリストル・マイヤーズ)、国内初の「 ...

09/30 06:16 経腸栄養療法分野の胃瘻関連製品「エンドビブ」シリーズ4製品 ボストン・サイエンティフィック - 薬事日報
09/30 06:16 経腸栄養療法分野の胃瘻関連製品「エンドビブ」シリーズ4製品 ボストン・サイエンティフィック - 薬事日報

薬事日報

経腸栄養療法分野の胃瘻関連製品「エンドビブ」シリーズ4製品 ボストン・サイエンティフィック
薬事日報
税別希望販売価格は、胃瘻造設用カテーテルの「エンドビブ・セルジンガーPEGキット」が胃壁固定具なし3万5000円、胃壁固定具つき4万7000円、「エンドビブ・PEGキット」8万円。交換用カテーテルの「エンドビブ・ボタンII」2万5900円、「エンドビブ・バンパーGチューブ」2 ...

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2017/02/10 09:03 葉酸 peg - NAVERまとめ
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10/02 22:29 感謝しています もう少しお願いしたいです Surface Plasmon Resonance Measurement...
10/02 22:29 感謝しています もう少しお願いしたいです Surface Plasmon Resonance Measurement...
感謝しています もう少しお願いしたいです Surface Plasmon Resonance Measurements. The selective interaction of CD-PEG-FA with the cow milk folate binding protein (FBP) was investigated by surface plasmon resonance analysis. The surface plasmon resonance profiles relative to â-cyclodextrins, â-cyclodextrins/PEG, and CD-PEG-FA reported in Figure 2 display a low signal/noise ratio typical of low molecular weight compounds, which elicit a weak signal. The signal variation (RU) at the injection time was due to irregularities induced by the injection of a solution with different refractive index compared to that of the solvent. To avoid this abnormality, the association curves were analyzed with a delay time of 9.9 s. Despite the high noise, the surface plasmon resonance profiles reported in Figure 2A show differences among CD-PEG-FA, â-cyclodextrins, and the â-cyclodextrins/ PEG mixture. The CD-PEG-FA bioconjugate elicits a signal due to a specific interaction with the FBP immobilized on the sensor chip, whereas the unconjugated â-cyclodextrins, either in the presence or in the absence of PEG, elicit a very weak signal indicating that no binding takes place. The plasmon resonance signal/noise ratio did not allow for an accurate evaluation of the CD-PEG-FA apparent dissociation constant for FBP. However, the bioconjugate was estimated to have approximately 400 times lower affinity constant for FBP compared to the free folic acid value reported in the literature (25). Specific binding of CD-PEG-FA to immobilized FBP was also demonstrated by injection of the conjugate in the presence of an excess of free folic acid (CD-PEGFA/ folic acid 1:25 molar ratio). The plasmon resonance profiles obtained with CD-PEG-FA in the absence or in the presence of free folic acid reported in Figure 2B indicate that the amount of CD-PEG-FA bound to FBP was sensibly lower in the case of folic acid co-injection, suggesting that the free folic acid competes with CDPEG- FA for FBP binding.

10/02 22:24 お願いします To get more information about intracellular trafficking of deliv...
10/02 22:24 お願いします To get more information about intracellular trafficking of deliv...
お願いします To get more information about intracellular trafficking of delivered rhodamine-B, KB cells were incubated for 1 h of pulse contact with medium containing rhodamine-B included CD-PEG-FA. Figure 5C shows that red fluorescence in dispersed cytosolic small spots, probably corresponding to small endosomes, was detectable soon after incubation. After 1 h, larger cytosolic fluorescent areas were observed (Figure 5D) indicating that the endosomes migrate and are localized in proximity of the Golgi apparatus as reported in the literature . Rhodamine-B uptake by KB cells (A) and MCF7 cells (B). Fluorescence increase after cell incubation with free rhodamine-B and rhodamine-B complexed with â-cyclodextrins/ PEG 1:1 molar ratio mixture, CD-PEG-FA, and â-cyclodextrins/ PEG/folic acid 1:1:1 molar ratio mixture. The fluorescence increase is referenced to the values obtained with â-cyclodextrin complexed rhodamine-B. The mean values and the standard deviations were calculated on the basis of five experiments: P < 0.02 (///); P < 0.05 (//); P < 0.5 (/). Cell Toxicity Investigations. Aimed at setting up proper cell culture protocols for evaluating the cell binding and uptake, investigations were undertaken by incubation of PEG, folic acid, â-cyclodextrins, â-cyclodextrins/ PEG/folic acid 1:1:1 molar ratio mixture, and CDPEG- FA with folate receptor overexpressing KB cells or folate receptor nonexpressing MCF7 cells. As expected, samples containing free folic acid displayed enhanced cell proliferation while PEG did not have any effect on cell viability. Also, neither â-cyclodextrins nor CD-PEG-FA was found to affect the cell viability under the experimental conditions.

10/02 22:23 何個もすいませんがお願いします The bioconjugate selectivity for the folate re...
10/02 22:23 何個もすいませんがお願いします The bioconjugate selectivity for the folate re...
何個もすいませんがお願いします The bioconjugate selectivity for the folate receptor overexpressing cells was confirmed by using MCF7 cells, a human lung carcinoma cell line that lacks the folate receptor. The test was carried out under the same conditions reported above for the KB cell studies. Figure 4B shows that low cell-associated fluorescence is observed after incubation with free rhodamine-B and with rhodamine- B complexed with â-cyclodextrins/PEG or with â-cyclodextrins/PEG/folic acid, as well as after incubation with rhodamine-B loaded CD-PEG-FA. These results indicate that in this case the fluorophore was not taken up actively by cells. Figure 5 shows the confocal laser-scanning microscopy images obtained after cell incubation with rhodamine-B loaded CD-PEG-FA and rhodamine-B loaded â-cyclodextrins/ PEG/folic acid. The cell membranes were greenstained by fluorescein-DHPE, while red fluorescence was related to taken-up rhodamine-B. Figure 5A shows that CD-PEG-FA promotes the rhodamine-B localization into KB cell tubular endosomal structures, some of them having a thickness of about 1-2 ím similar to those reported by other authors (27). Also, multivesicular bodies with predominant perinuclear fluorophore disposition were observed. Very weak diffuse fluorescence was detected in the cytosolic compartment and without localization into the nuclei. In contrast, the images obtained after KB or MCF7 cell incubation with free rhodamine-B, rhodamine-B loaded â-cyclodextrins/ PEG, and â-cyclodextrins/PEG/folic acid mixtures or after MCF7 cell incubation with rhodamine-B loaded CDPEG- FA did not show specific rhodamine-B localization into tubular endosomal structures and multivesicular bodies. In these cases, a diffused fluorescence in the cyctosolic compartment was observed. As an example, Figure 5B reports the image obtained with KB cells incubated with rhodamine-B loaded â-cyclodextrins/PEG/ folic acid.

10/02 01:13 お願いします いろいろとすいません β-Cyclodextrins, folic acid, and PEG were ...
10/02 01:13 お願いします いろいろとすいません β-Cyclodextrins, folic acid, and PEG were ...
お願いします いろいろとすいません β-Cyclodextrins, folic acid, and PEG were properly assembled to obtain a supramolecular carrier system for active drug delivery. The delivery system was designed in order to exploit the physicochemical and biological properties of the various components; the β-cyclodextrin unit can host drugs with low solubility and stability, folic acid allows for active targeting to folate receptor overexpressing tumor cells, and PEG was used as a spacer between β-cyclodextrin and folic acid. PEG confers to the targeting moiety a certain flexibility that overcomes problems related to steric hindrance of β-cyclodextrin. Furthermore, PEG endows a derivative with higher solubility compared to the naked â-cyclodextrin or folic acid. The solubility of the new construct in water is, in fact, about 100 mg/mL, while the solubility of â-cyclodextrins and folic acid is 18.5 and 0.0016 mg/mL, respectively. The bioconjugate was found to maintain high affinity for rhodamine-B used as the fluorescent probe in the present study. This result is in agreement with the data relative to estradiol already published . Similarly to estradiol, the rhodamine-B affinity constants for naked â-cyclodextrins and CD-PEG-FA were in the same order. However, the slight decrease in affinity obtained with CD-PEG-FA may be attributable to the chemical modification of the oligosaccharide ring or to the presence of the bound PEG that can interfere with the drug association, though the PEG and folic acid physically mixed with the β-cyclodextrins were not found to affect significantly the rhodamine-B affinity constant.

10/02 01:10 とても助かります 研究されてるのでしょうか? The enzymatic cell detachment pro...
10/02 01:10 とても助かります 研究されてるのでしょうか? The enzymatic cell detachment pro...
とても助かります 研究されてるのでしょうか? The enzymatic cell detachment procedure avoided fluorescence interferences due to unspecific rhodamine-B absorption on the plastic material. Rhodamine-B concentrations below 2 íM were used to prevent rhodamine-B related cell toxicity. Finally, methylene blue assay usedto evaluate the cell viability avoided absorbance interferences observed with the MTT assay . Figure 4A shows the KB cell-associated fluorescence values obtained after incubation with free rhodamine-B or rhodamine-B included in β-cyclodextrins/PEG, β-cyclodextrins/ PEG/folic acid, and CD-PEG-FA. The data reported in the figure were obtained by subtracting the values obtained with rhodamine-B loaded β-cyclodextrins, which displayed the lower cell-associated fluorescence. The increase of cell-associated fluorescence obtained with free rhodamine-B indicates that the passive penetration of the probe into the cells is prevented by inclusion into naked β-cyclodextrins. PEG and folic acid were found to enhance the cell uptake of rhodamine-B loaded β-cyclodextrins. The uptake of rhodamine-B loaded CD-PEG-FA was significantly higher (P < 0.02) compared to that under other experimental conditions: 19% higher with respect to rhodamine-B loaded β-cyclodextrins, 12% higher compared to free rhodamine-B, more than 10% higher compared to β-cyclodextrins/PEG and â-cyclodextrins/PEG/folic acid mixtures.

10/02 01:05 お願いします [3H]-folic acid competition binding profiles of cellular folate ...
10/02 01:05 お願いします [3H]-folic acid competition binding profiles of cellular folate ...
お願いします [3H]-folic acid competition binding profiles of cellular folate receptor obtained with monolayer KB cells incubated with cyclodextrin/PEG 1:1 molar ratio (■) and CD-PEG-FA (▲). The mean values and standard deviations were calculated on the basis of five experiments. Competition Binding Studies. [3H]-folic acid/CDPEG- FA or [3H]-folic acid/[β-cyclodextrins/PEG 1:1 molar mixture] binding competition studies were undertaken using KB cells to evaluate the CD-PEG-FA affinity for the cell folate receptor. The [3H]-folic acid binding competition profiles reported in Figure 3 show that β-cyclodextrins/PEG do not compete with [3H]-folic acid for the cell receptor. The maximal cell-associated radioactivity due to [3H]-folic acid binding to the cell receptors was in fact retained at high [β-cyclodextrins/PEG mixture] concentrations (log [host], íM). In contrast, the cellassociated radioactivity decreased as the CD-PEG-FA concentration increased, indicating that the bioconjugate displaced the [3H]-folic acid from the cell receptor. Since 50% of cell-associated radioactivity was obtained with 1.4 íMCD-PEG-FA and 0.1 íM [3H]-folic acid, CD-PEGFA was estimated to maintain 7% of the residual affinity for cell folate receptor. Cell Uptake Investigations. Cell uptake studies were carried out by incubation of free rhodamine-B,rhodamine-B included in CD-PEG-FA, and various mixtures of the individual components (β-cyclodextrin, PEG, folic acid, and rhodamine-B) with folate receptor overexpressing KB cells or folate receptor not expressing MCF7 cells. According to the results reported in Figure 1A, 1:100 rhodamine-B/β-cyclodextrin molar ratio was chosen to guarantee over 90% of rhodamine-B inclusion into β-cyclodextrins or into CD-PEG-FA.

10/01 02:25 ちょっとした文章ですが、訳せる部分をお願いしてもよろしいでしょうか? 翻訳サイ...
10/01 02:25 ちょっとした文章ですが、訳せる部分をお願いしてもよろしいでしょうか? 翻訳サイ...
ちょっとした文章ですが、訳せる部分をお願いしてもよろしいでしょうか? 翻訳サイトではない訳を教えてください。 ①The supramolecular carrier obtained by β-cyclodextrins, PEG 700 Da, and folic acid bioconjugation possesses interesting properties for active tumor targeting. ②The copresence of the three components in the same construct enhances the drug solubility and stability and promotes drug targeting to the disease site, receptor recognition, and intracellular delivery. ③The drug release into the cells occurs by physical displacement, which represents a further advantage of this delivery system because chemical or enzymatic mechanisms usually required for drug release from polymer therapeutics often entail ineffective drug release. ④Interestingly, the physicochemical and biopharmaceutical properties of this new class of bioconjugates can be optimized by the proper choice of the construct components over a wide range of materials: cyclodextrins, polymeric spacer arms, and targeting moieties. ⑤Furthermore,according to the physicochemical properties of the drug and the target disease, tailor-made supramolecular carriers can be prepared.

10/01 02:23 お手数ですがお願いします (A) Fluorescence quenching curve-fitting of rhodamin...
10/01 02:23 お手数ですがお願いします (A) Fluorescence quenching curve-fitting of rhodamin...
お手数ですがお願いします (A) Fluorescence quenching curve-fitting of rhodamine- B with β-cyclodextrins (・×), β-cyclodextrins/PEG/folic acid 1:1:1 molar ratio mixture (■), and CD-PEG-folic acid (▲). (B) Modified Benesi-Hildebrand plots of rhodamine-B complexation with â-cyclodextrins (・×), β-cyclodextrins/PEG/folic acid 1:1:1 molar ratio mixture (■), and CD-PEG-FA (▲). Host-Guest Inclusion Constant Determinations. The formation of â-cyclodextrins and CD-PEG-FA inclusion complexes with rhodamine-B was investigated by fluorimetric titration . Figure 1A shows the quenching profiles of rhodamine-B in the presence of different concentrations of â-cyclodextrins, â-cyclodextrins/PEG/folic acid 1:1:1 molar ratio mixture, and CD-PEG-FA. Figure 1B reports the quenching value elaboration used to calculate the inclusion constants of rhodamine-B for â-cyclodextrins, â-cyclodextrins in the presence of PEG and folic acid and CD-PEG-FA. The complex stability constants were determined according to the modified Benesi-Hildebrand equation assuming a 1:1 rhodamine-B/cyclodextrin stoichiometry described by the following equation: where [RhB]0 and [CDs]0 are the initial guest (rhodamine- B) and host (â-cyclodextrin or CD-PEG-FA) concentrations, respectively, F0 and F are the fluorescence intensities in the absence and in the presence of host, respectively, F¥ is the fluorescence intensity limit when all rhodamine-B was included in the â-cyclodextrins, and Ks is the inclusion constants for 1:1 complex. The complex stability constants of rhodamine-B for â-cyclodextrins, â-cyclodextrins/PEG/folic acid, and CDPEG- FA were calculated to be 4580, 4500, and 3000M-1, respectively. Importantly, the calculated inclusion constant of rhodamine-B for â-cyclodextrins corresponds fairly to the value reported in the literature

09/30 01:05 うまく日本語が作れなく困っています。 訳をお願いします。 Specific Antitumor Ta...
09/30 01:05 うまく日本語が作れなく困っています。 訳をお願いします。 Specific Antitumor Ta...
うまく日本語が作れなく困っています。 訳をお願いします。 Specific Antitumor Targetable â-Cyclodextrin-Poly(ethylene Glycol)-Folic Acid Drug Delivery Bioconjugate The tumor targeting properties of a new drug carrier synthesized by bioconjugation of folic acid (FA) to â-cyclodextrins through a poly(ethylene glycol) (PEG) spacer (CD-PEG-FA) were investigated. Surface plasmon resonance demonstrated that CD-PEG-FA specifically interacts with immobilized folate binding protein (FBP) while the naked â-cyclodextrins do not display any specific interaction. In vitro studies demonstrated that CD-PEG-FA was devoid of cell toxicity. [3H]-folic acid/CD-PEGFA competition binding investigations performed with folate receptor overexpressing human epidermal carcinoma KB cells showed that CD-PEG-FA had about 14 times lower tumor cell binding capacity than free folic acid. The carrier cell trafficking properties were investigated using rhodamine-B as fluorescent probe, which possesses 3000 and 4580 M-1 inclusion constants for CD-PEG-FA and â-cyclodextrins, respectively. Cell-associated fluorescence measurements showed that CD-PEG-FA does not promote the rhodamine-B uptake into non-folate receptor expressing human lung carcinoma MCF7 cells while 19% higher accumulation in KB cells was found with respect to rhodamine-B loaded â-cyclodextrins. Confocal laser scanning microscopy indicated the presence of cytosolic red fluorescent spots after 2 h of incubation of KB cells with rhodamine-B included CD-PEG-FA. The fluorescent dye resided primarily in small spots, namely, endosomes and multivesicular bodies. At 1 h after pulsed incubation, wider red fluorescent cellular structures appeared as a fusion of previous structures.

09/30 00:54 専門の方日本語にしてもらえますか? 訳せるところだけでも、お願いします。 ①The...
09/30 00:54 専門の方日本語にしてもらえますか? 訳せるところだけでも、お願いします。 ①The...
専門の方日本語にしてもらえますか? 訳せるところだけでも、お願いします。 ①The folate receptor mediated endocytosis was largely investigated to expand the therapeutic value of drugs by increasing delivery to the target tissue as well as the target/nontarget tissue ratio. ②Examples of targetable drug delivery carriers functionalized by folic acid conjugation include radionuclide deferoxamine-folate complexes for radiopharmaceutical imaging, liposome-folate encapsulated drugs, liposome-folate encapsulated polylysine- DNA, cytotoxin-folate conjugates and folic acid decorated nanoparticles. ③Recently, we synthesized a new targetable drug delivery system by folic acid conjugation to â-cyclodextrins through a 700 Da poly(ethylene glycol) (PEG) spacer arm. ④Preliminary studies demonstrated that the derivative possesses suitable properties for drug delivery: high solubility, ability to form inclusion complexes with few drug models, and negligible hemolytic activity . ⑤In the present study the biological and biopharmaceutical properties of the new β-cyclodextrin-PEG-folic acid bioconjugate were investigated. ⑥The affinity of the bioconjugate for the immobilized folate binding protein (FBP) and for the cell membrane folate receptor was determined by Biacore and cultured tumor folate receptor overexpressing KB cells, respectively. ⑦The ability of the conjugate to be taken up by folate receptor overexpressing and nonexpressing cells was also investigated, and its intracellular localization was determined. お願いします。

2017/02/10 08:59 「葉酸 peg」の検索結果 - Yahoo!ニュース

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2017/02/10 08:58 [アメーバサーチ] 葉酸 pegの検索結果

01/15 10:00 美肌のミカタ!ローヤルゼリー1
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・・・パックに1000mgのローヤルゼリーと、GABA、マカ、葉酸、 ビタミンC・Eなど、ライフステージをサポ・・・ 容 23g 全 成 分 水、グリセリン、PEG/PPG?17/6コポリマー、エリスリトール、ハマメリス樹皮/・・・

2017/02/10 08:57 [葉酸 peg]の検索結果 - goo検索

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